Patriarchate and church administration
Spyridon received episcopal consecration from Saint Ephraim II, the Bulgarian-born Athonite ascetic who had twice been called to the Serbian patriarchal throne. Ephraim's withdrawal into monastic silence opened the way for Spyridon's elevation, and the same Ephraim resumed leadership of the Serbian Church after Spyridon's repose.
Sources note some uncertainty about Spyridon's earlier life: by one account he was born in Niš and may have served as a metropolitan in the 1370s before his elevation, though these details are not firmly established. The dates of his patriarchate likewise vary in the sources, with the OCA synaxarion giving 1382 to 1388 and other accounts extending his tenure to the year of the Battle of Kosovo.